From the rhizomes of B. ligulata only bergenin and b-sitosterol have been isolated. The rhizomes of B. ciliata yield gallolylated leucoanthoeyanidin-4-(2-galloyl) glucoside as well. The roots of B. stracheyi contain a new catechin derivative (+) catechin-3- gallate.

From the rhizomes of B. ligulata only bergenin and b-sitosterol have been isolated. The rhizomes of B. ciliata yield gallolylated leucoanthoeyanidin-4-(2-galloyl) glucoside as well. The roots of B. stracheyi contain a new catechin derivative (+) catechin-3- gallate.

Botanical Name Bergenia ligulata
Common Name Pashanbhedi
Local Name Zakhmi-Hayat
Botany Rhizomes
Chemistry
From the rhizomes of B. ligulata only bergenin and b-sitosterol have been isolated. The rhizomes of B. ciliata yield gallolylated leucoanthoeyanidin-4-(2-galloyl) glucoside as well. The roots of B. stracheyi contain a new catechin derivative (+) catechin-3- gallate.
Folklore Uses
Its anti-inflammatory property finds a use in the treatment of abscesses and cutaneous infections. It is also used in the treatment of dysentery and diarrhoea.
Medicinal Uses
The antilithic property of the crude extract has been investigated by several workers(4,5) Shah et al concluded that the alcoholic extract had no effect in preventing stone formation in rats (after the method of Lyon)(6) but was of significant help in dissolving preformed stones. Low doses of Pashanabheda extract (0.5 mg/kg of alcoholic extract) promote diuresis in rats, but higher doses 100 mg/kg reduce the urine output, and also reduce the diuresis produced by urea(7). In rats(7), the extract reduced spontaneous motor activity and besides its own analgesic action it also potentiated morphine analgesia. However, it had no protective effect against convulsions produced by pentylene tetrazol or electric shock. There is significant CNS depressant activity in the crude extract(7) .The alcoholic extract displays marked anti-bradykinin activity although it does not affect the action of 5-HT and acetylcholine on isolated guinea pig ileum. It has been shown to potentiate the action of adrenaline on guinea-pig trachea and ileal muscle. The alcoholic extract has a marked anti-inflammatory(7) effect on the response to various forms of experimental injury. The anti-inflammatory effect of the extract, like its diuretic effect, is reduced when higher doses of the drug are employed(4). There is also a mention of antiviral activity against influenza-A virus(8). In ayurvedic practice, Pashanabheda, as its name suggests, is used as a litholytic agent for urinary calculi. It is widely used in the treatment of dysuria and renal failure, cystitis and crystalluria. Its anti-inflammatory property finds a use in the treatment of abscesses and cutaneous infections. It is also used in the treatment of dysentery and diarrhoea. CONTRAINDICATION : Its cardiotoxic, antidiuretic and CNS depressant action on experimental models have been reported with large doses. It is unlikely that these effects will be encountered with the doses in clinical use. In rats, the LD(50), of the aqueous extract was 650 mg/kg intraperitoneally.